Chicken Bubble Biscuit Bake Casserole

Update : February 6, 2026

why make this recipe

Chicken Bubble Biscuit Bake Casserole is a comforting and hearty dish perfect for family dinners or gatherings. It combines tender chicken, creamy sauce, and fluffy biscuits into one delicious meal. It’s easy to prepare, making it a great choice for busy weeknights. Plus, you can enjoy leftovers the next day!

how to make Chicken Bubble Biscuit Bake Casserole

Ingredients :

2 cups cooked chicken (shredded or diced (rotisserie works great))
1 10.5 oz can cream of chicken soup (or cream of mushroom)
1/2 cup sour cream (or plain Greek yogurt)
1/2 cup milk
1 cup frozen mixed vegetables (peas, carrots, corn, beans)
1 tsp garlic powder
1/2 tsp onion powder
Salt & pepper (to taste)
1 16 oz can refrigerated biscuit dough, cut into quarters
1 cup shredded cheddar cheese (or mozzarella)
1 tbsp melted butter (optional, for brushing)

Directions :

Preheat oven to 350°F (175°C). Lightly grease a 9×13-inch baking dish.
Mix the filling: In a large bowl, combine cooked chicken, cream of chicken soup, sour cream, milk, vegetables, garlic powder, onion powder, salt, and pepper. Stir until smooth.
Add biscuits: Fold in the quartered biscuit pieces until they are coated in the mixture.
Assemble casserole: Pour everything into the prepared baking dish. Sprinkle shredded cheese evenly over the top.
Bake: Cover with foil and bake for 20 minutes. Remove the foil and bake an additional 10–15 minutes, until biscuits are puffed, golden, and cooked through.
Finish: Brush with melted butter if desired. Let cool slightly before serving.

how to serve Chicken Bubble Biscuit Bake Casserole

Serve this casserole warm right out of the oven. It pairs nicely with a simple green salad or some crusty bread for a complete meal. You can also top it with fresh herbs like parsley or chives for added flavor.

how to store Chicken Bubble Biscuit Bake Casserole

Store any leftovers in an airtight container in the refrigerator. It will stay fresh for about 3 to 4 days. To reheat, simply warm it in the oven at 350°F (175°C) until heated through. You can also microwave individual portions.

tips to make Chicken Bubble Biscuit Bake Casserole

Feel free to use leftover chicken or rotisserie chicken for quick preparation.
Customize the mixed vegetables based on your preferences or what you have on hand.
For extra flavor, add spices or herbs like thyme or rosemary.
If you like a crunchy topping, you can sprinkle breadcrumbs over the cheese before baking.

variation

You can make this casserole vegetarian by omitting the chicken and adding more vegetables like bell peppers, zucchini, or mushrooms. You can also try using different types of cheese to mix up the flavor.

FAQs

Can I use fresh chicken instead of cooked chicken?
Yes, you can use cooked chicken, but cook the chicken first before mixing it with the other ingredients.

Can I make this casserole ahead of time?
Yes, you can prepare the casserole ahead of time and store it in the fridge until you’re ready to bake it.

What should I do if I don’t have cream of chicken soup?
You can use cream of mushroom soup or any other cream soup as a substitute. You can also make your own creamy sauce using a roux and broth.